Pregnenolone is an extremely versatile natural cholesterol metabolism product and the precursor substance for several important endogenous messenger substances (hormones). Among other properties pregnenolone is the parent substance of sexual hormones (estrogen, testosterone), stress hormones (cortisone, cortisols) and DHEA. Since the quantity of pregnenolone produced in the body reduces with advancing age, the metabolic functions dependent on steroid hormones are also reduced. Regular supplementation of pregnenolone can re-activate these metabolic functions, exert a favorable effect on several diseases, and protect the body from age-related physical decline. Therefore, pregnenolone is considered to be a «fountain-of-youth» hormone like DHEA.
The metabolism of pregnenolone is very complex. All substances of this basic hormonal substance category have one feature in common, namely their chemically defined steroid structure. Pregnenolone is the first metabolic product that is formed after the absorption of fat from food or from the fatty substances (cholesterols) derived by this process. It is the most important element for the production of endogenous steroid hormones. As pregnenolone is a precursor substance, the organism always produces the quantity of steroid elements it currently needs. The quantity of pregnenolone available in the body (endogenous) reduces with advancing age; a gender-specific reduction has not been conclusively established.
Pregnenolone may be present in the body in unchanged form, or may be transformed into dehydroepiandrosterone (DHEA) and act as such. However, if necessary it can also be transformed into progesterone and utilized as such (progesterone regulates female sexual functions like the menstrual cycle).
This transformation into DHEA or progesterone occurs according to individual needs in the presence of psychological or physical stress, disease, or during specific phases of life (menopause), for the purpose of producing other hormones (stress and sexual hormones).
Some effects of pregnenolone such as the improvement of memory are attributed to the direct effects of pregnenolone. Nume-rous other effects probably occur indirectly through the hormonal substances resulting from pregnenolone.
Inflammatory joint disease (arthritis): Pregnenolone was successfully used to treat rheumatic joint disease in the 1940’s. In particular, pregnenolone was much better tolerated than cortisone, salicylates, gold and other antirheumatics.
Chronic fatigue, stress and exhaustion: Several studies show that a daily dose of 50 mg pregnenolone effectively improves states of fatigue and stress. Millions of individuals who have regularly taken low doses of pregnenolone have benefited from the properties of pregnenolone in terms of reducing stress and enhancing physical capacity. Besides, it is effective in cases of depression, states of anxiety, and sleep disorders.
Memory: Numerous studies conducted in the last 30 years showed that a low-dose administration of pregnenolone improves memory, particularly long-term memory. Therefore pregnenolone has also been termed the «smart drug». Apparently pregnenolone protects the body from age-related cerebral dysfunction and dementia such as Alzheimer’s disease. Healthy young persons who are frequently exposed to stressful situations may also utilize this quality of pregnenolone, namely its ability to enhance mental performance.
Menstrual symptoms: Since pregnenolone is a precursor substance of female sexual hormones (progesterone, estrogen), the administration of pregnenolone may exert a stabilizing effect on female sexual function, for instance in case of menstrual disorders or menopausal symptoms. After menopause pregnenolone provides a basic hormonal substance for women in a safer form – without the dreaded side effects of estrogen – and ensures the health of female sexual organs through its progesterone effects. Virilization effects through the administration of pregnenolone are extremely unlikely because pregnenolone is very marginally involved in the metabolism of male sexual hormones (androgens).
Symptoms of old age: Pregnenolone is considered to be an anti-aging substance because it may exert a favorable effect on age-related cognitive disorders, functional disorders of the body, and degradative processes. The effects probably occur indirectly through the hormonal substances resulting from pregnenolone.
Treatment with pregnenolone is recommended for all diabetics older than 40 years of age; occasionally it is also suitable for younger patients and those with juvenile diabetes. In experiments it was shown that pregnenolone restores the beta-cells of the pancreas and may thus be beneficial in patients with diabetes.
- The additional intake of DHEA enhances the effect of both substances because pregnenolone is a direct precursor of DHEA.
- Pregnenolone may also be used optimally in conjunction with melatonin (with or without DHEA): Pregnenolone activates energy and performance capacity during the day.
Melatonin guarantees the recovery of energy when the individual rests at night. Both hormones ensure energy balance, stress control and relaxation, and enhance the power of resistance to health disorders in all regions of the body up to an advanced age.
One capsule contains 15 mg, 30 mg, 50 mg, 100 mg or 200 mg pregnenolone in pharmaceutical grade. Other ingredients: rice flour, magnesium stearate.
The exact dosage of Pregnenolone can be decided only after an individual hormone status has been determined. The intake may be started from the age of 25 years.
In normal cases take 1 capsule daily in the morning with plenty of fluid.
No side effects are expected to occur at the recommended dose. Caution is advised in persons who suffer from epilepsy because pregnenolone may, in theory, cause convulsions.
Pregnenolone is a hormone preparation produced in accordance with the most recent scientific discoveries. It is a food supplement for regular use. Pregnenolone contains no harmful colorants, filling materials or preservatives, and is manufactured under most stringent safety controls. The prolonged release (time release) of the active substance makes pregnenolone uniformly available for the body throughout the day.
Pregnant or lactating women or persons who are under constant medical care should consult a doctor before use. In principle, hormones should be taken only under the supervision of a -doctor. Store in a cool, dry place and keep out of reach of children.