Thermoslim® Info

Basic Facts
Effects
Indications
Composition
Dosage
Side Effects/Contraindications
Instructions

BASIC FACTS

One of the big macroeconomic problems in the Western industrialized countries is overweight. More than half of all people are meanwhile affected by this problem. At fault are a lack of exercise, stress as well as false and unbalanced nutrition. Overweight people run a much higher risk of suffering from cardiovascular diseases, diabetes and disturbances of the fat metabolism, and the costs for treating these secondary diseases add up to billions for the state health systems. Overweight is therefore not only annoying because it contradicts the current beauty ideals but a serious medical and economic problem.

A mere restriction of the calories of the food can by itself reduce overweight. However, the decrease of the fat reserves resulting from a shortage of calories leads to an alarm reaction of the fat cells which, by producing messenger substances, report the «hunger state» to the brain. Therefore, a weight reduction brought about by reducing the intake of calories is often followed by a phase of ravenous hunger in which more food is eaten so that within short the effect of the diet is gone. A promising long-term strategy against overweight must start with the fat cell itself by triggering within that cell a readjustment of its metabolism through natural signals.

According to Dr. Jean-Paul Descypere, professor for nutritional science at the university of Gent, diets may be the main cause of obesity. Often the only effect of weight-reducing diets is a subsequent increase in weight. More than 90 % of all people who have lost weight with a diet gain that same weight again within a period of five years, and sometimes they even gain more weight than they previously lost (yo-yo effect).

Of course, a well-balanced nutrition is necessary to get overweight under control in the long run, but calorie-reduced diets alone just cause the metabolism and the body’s own burning of fat to slow down, which is exactly what is often the cause of overweight.

The preparation Thermoslim^® consists of the extract of the Chinese plant Citrus aurantium, which in the traditional medicine of the Far East is used to treat digestive disorders. This plant, which in China is called «Zhi Shi», has been used as a medicine for digestive disorders, gastrointestinal complaints as well as to improve the blood circulation and the liver functions for thousand of years.

Now it has been found that the active ingredients of the plant accelerate the reduction of the stored fat and, therefore, can be successfully used to fight overweight without triggering a stress or alarm reaction in the body. The combination of five amino compounds contained in «Zhi Shi» is an ideal aid that helps to simultaneously reduce weight and build up muscle substance.

The preparation Thermoslim^® provides the unique «Zhi Shi» formula, and it accelerates the fat burning mechanism in the body without having the dangerous side effects of various diet preparations since it stimulates the metabolism without increasing the heart rate and the blood pressure.

EFFECTS

The effects of the hormones of the sympathetic nervous system, adrenalin and noradrenalin, in the organism are manifold. Best known are the obvious effects under stress or nervousness, such as an accelerated pulse, outbreak of sweat and pallor (narrowing of the vessels of the skin). But also the reduction of fat is accelerated by these hormones in order to mobilize energy reserves for the fight situation. The sympathetic metabolic condition is tuned to active situations in which one has to fight or flee. This leaves little time for eating and digesting and therefore the feeling of hunger is also suppressed by the hormones of the sympathetic nervous system.

A further important effect of adrenalin and noradrenalin is also subsumed under the term «thermogenesis». Thermogenesis is the production of heat or energy in the cells of the body having a direct connection with the metabolism. Thermogenesis activates the cells of the brown adipose tissue (= BAT cells), and this process varies depending on the temperature of the surrounding, the meals and possibly also the time of the day.

Like the heart, the blood pressure, the lung function and other vital activities, also thermogenesis is controlled by the SNS (sympathetic nervous system). As mentioned above, the main transmitters of the SNS are adrenalin and noradrenalin. These neurotransmitters stimulate thermogenesis via certain receptors which sit on the surface of the BAT cells. Simplified, one can divide these receptors into five groups:

Alpha-1 receptors: induce the arteries to narrow, which may increase the blood pressure.
Alpha-2 receptors: act on the blood pressure by narrowing the peripheral blood vessels.
Beta-1 and beta-2 receptors: influence the functions of the heart, cause the lung vessels and the blood vessels in the heart muscle and in the skeletal muscles to enlarge.
Beta-3 receptors: cause the separation of white fat from the fat pads (lipolysis = fat metabolism) and accelerate the metabolism and therefore also thermogenesis, which intensifies the burning of fat.

But all known substances having the positive effect of activating beta-3 receptors and therefore also the removal of fat (ephedrine, amphetamines, various diet medicines) also stimulate all other receptors and in this way cause undesired and partly even dangerous side effects. An ideal substance to reduce fat and consequently also the weight should therefore influence beta-3 receptors but have no effect on all others.

Various anorectic agents and weight loss products, but also doping substances are therefore based on the principle of these natural hormones. But who wants to put up with outbreaks of sweat, increased pulse rates and possibly a rise in blood pressure when attempting to lose weight. Overweight people having a disturbed fat metabolism in particular should not additionally stress their heart!

Pharmacologists finally found out that also the b-receptors themselves are not uniform and can be broken down into beta-1 (lung), beta-2 (glands) and beta-3 (fat cells). What a surprise that the site of action of amines from Citrus aurantium (synephrine, octopamine, hordenine, methyltyramine and tyramine) is almost exclusively the beta-3-receptors! Fat reduction in the white fat cells is thereby accelerated in a natural way without stressing the heart.

INDICATIONS

Thermoslim^® is intended to treat overweight, especially if a disturbed fat metabolism or a previous damage of the heart does not allow the use of conventional anorectic agents.

It is, however, not meant to replace a responsible and critical way of life which sets store on a well-balanced, healthy and sensible nutrition but to be used as a meaningful supplement and support.

COMPOSITION

One capsule contains 350 mg extract from the fruit of the bitter orange (Citrus aurantium) in pure pharmaceutical quality in microcristalline cellulose.

DOSAGE

In normal cases take 1–2 capsules 2–3 times a day 1 hour before mealtimes with plenty of fluid.

SIDE EFFECTS/CONTRAINDICATIONS

In the dosage mentioned, the preparation is generally well tolerated.

INSTRUCTIONS

Nutritional scientists recommend, as they do with all diet products, to additionally take a multivitamin preparation. Generally, a specialist should be consulted before intake. In the presence of diseases or when taking medications on a long-term basis, Thermoslim^® should in any case be used only after consulting the treating doctor. If you develop any symptoms while taking this preparation, you should consult a doctor and inform him/her of the intake.

This product is available at pharmacies or via Pharmatrans Inc.

For information about prices and packing sizes click here.